The school is similar to an average school, with a playground, gym, classrooms, and others. The principal is a strict teacher named Albert Green. However, in Season 4, he was replaced by his step-son, the much nicer Mark Leone.
In the Season 1 comic "Locker 239", the 2nd Grade student Mark Sanders accidentally drove right into the side of the school with his mother's car. Two years later, in the Season 4 comic "The Amnesia Act of 2015", the area that was destroyed is covered with caution tape.
The school is no longer a main setting in the series starting with Sibling Rivalries: The Next Chapter, as the protagonist of the series, Patrick "Packie" McReary promoted from WES in May 2016, and now attends Green Bay Southwest High School starting from August 2016. WES will still make minor appearances now and then, as Packie's younger siblings still attend the school in their last few years there, and Packie will visit a couple of times.
- Albert Green - Principal (? - 2013)
- Mark Leone Jr. - Principal (2014 - present)
- Michael Jacob - 5th/6th Grade Math Teacher (? - present)
- Charlie Richards - 5th/6th Grade Science Teacher (? - present)
- Amanda Pratt - 5th/6th Grade Language Arts Teacher (? - present)
- Leslie Stevens - 5th/6th Grade Social Studies Teacher (? - present)
- Scott Hill - Gym Teacher (some time after 2012 - present)
- "Locker 239" is the first comic to take place entirely at the school (during three days).
- "The Lockdown" is the second comic to only take place at the school.
- Sibling Rivalries Pre-Series
- Sibling Rivalries Main Series
- The McRearys Get Schooled! (first appearence; exterior and Mr. Jacob's classroom seen)
- Frightful Football Reunions (playground seen)
- Diamonds in the Rough (exterior and Mr. Jacob's classroom seen)
- Locker 239 (hallway, school auditorium, Mr. Jacob's classroom, and playground seen)
- San Salvador's Story (hallway seen)
- The Football Faker (cafeteria seen)
- Love is What Makes the World Go 'Round (exterior and cafeteria seen)
- Dodgeball Mishap (gym seen)
- Field Trip Gone Wrong! (exterior, Mr. Jacob's classroom and playground seen)
- Patrick McReary: School President (exterior, hallway, Mr. Jacob's classroom, and Mr. Leone's office seen)
- Wouldn't It Be Nice? (updated exterior, Mr. Jacob's classroom, Mr. Richards' classroom, and hallway seen)
- The Amnesia Act of 2015 (exterior, hallway and boys' restroom seen)
- One Tough Break-Up (exterior and cafeteria seen)
- Feeling Peachy (hallway seen)
- Trading Places (exterior, playground, Miss Lee, Mrs. Pratt, and the unnamed Math Club classrooms seen)
- A Christmas Story (exterior, hallway, and cafeteria seen)
- The Lockdown (exterior, cafeteria, hallway, boys' restroom, Mr. Leone's classroom, and various classrooms seen)
- Satellite Screw-Up (exterior and boys' restroom seen)
- ApRiL fOoLs DaY: wIsCoNsIn StYlE! (hallway and Mr. Jacob's classroom seen)
- Sibling Rivalries The Next Chapter