The fifth and final season of the Sibling Rivalries series ran from December 2, 2015 to February 7, 2016. Originally, this season only had four comics ("Trading Places", "A Christmas Story", "Straight Outta Green Bay", and "Best Frenemies"), until four comics from the cancelled Season 6 were added to Season 5, making the total of the season eight comics.
As the franchise will move forward with Sibling Rivalries: The Next Chapter, this makes this the last season of the original series.
- Patrick McReary (8/8)
- Francis McReary (8/8)
- Gerald McReary (8/8)
- Derrick McReary (8/8)
- Kate McReary (8/8)
- Maureen McReary (6/8)
- Hector Wilson (6/8)
- Aiden Wilson (6/8)
- Angel Chacon (7/8)
- Salvador Real (6/8)
- Joel Gonzales (6/8)
- Fred Wilson
- Valerie Wilson
- The Chavez Brothers
- Maria Arrayga-Tena
- Cesar Tena
- Cameron O'Neill
- Ethan O'Neill
- Chloe O'Neill
- Dillon O'Neill
- Aaron O'Neill
- Robert O'Neill
- Trading Places (Release date: December 2, 2015)
- A Christmas Story (Release date: December 22, 2015)
- Straight Outta Green Bay (Release date: January 25, 2016)
- Best Frenemies (Release date: February 7, 2016)
- Uncle Cameron Moves In (Release date: February 18, 2016)
- The Lockdown (Release date: February 29, 2016)
- Satellite Screw-Up (Release date: March 22, 2016)
- ApRiL fOoLs DaY: wIsCoNsIn StYlE! (Release date: April 10, 2016)
- Once again, a Five Star notebook is used for a season of the series, just like Season 1 and Season 4.
- On the season's cover, the five siblings posed in the same way that they did in the family portrait that was taken in the Season 4 comic "Wouldn't It Be Nice?".
- This is the first time that the Wisconsin Elementary School appears on a season artwork.
- Jose Gonzales appears in every comic of Season 5, becoming a new record.