Bernadette "Bernie" Rostenkowski-Wolowitz is one of the main characters on The Big Bang Theory. She is the beautiful wife (former girlfriend) of Howard Wolowitz. She is a microbiologist (she studies small living things), and Howard jokes that Bernadette should study HIM. She has a cute voice, but when she gets angry her voice sounds like Howard's mother. Bernadette has a lot of paitence with Sheldon Cooper.