Events that occur in 2000.
- The events of Grand Theft Auto Advance occur.
- Johnny Klebitz is arrested for parole violation.
- Patrick McReary and Dimitri Rascalov are arrested for hijacking (although not together).
- In Hello, Wisconsin!, Packie finds a picture of his older brother, which was taken March 6, 2000. Francis would be only 6 months old when this picture was taken.
- Salvador Real Arrayga is born on October 27 in Mexico City, Mexico.
- Jason Parker is born on November 5 in Avondale, Arizona.
- Others characters such as Eduardo Tena, Claude, Drake Romero, Steve Madison, Wendy Delgado, Joshua Jackson, Eric Serrato, Braulio Guillen, and a few other 7th Graders in Sibling Rivalries (as of 2013) were born in this year.